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Version: 17.06d (Release date: 2017-06-26)
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Mifamurtide (Code C1394)

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Terms & Properties

Preferred Name: Mifamurtide

Definition: A liposomal formulation containing a muramyl dipeptide (MDP) analogue with potential immunomodulatory and antineoplastic activities. Muramyl tripeptide phosphatidylethanolamine (MTP-PE), a derivative of the mycobacterial cell wall component MDP, activates both monocytes and macrophages. Activated macrophages secrete cytokines and induce the recruitment and activation of other immune cells, which may result in indirect tumoricidal effects. Liposomal encapsulation of MTP-PE prolongs its half-life and enhances tissue targeting.

NCI-GLOSS Definition: A drug being studied in the treatment of young adults with bone cancer that has gotten worse or come back. L-MTP-PE activates certain types of white blood cells and helps the immune system kill cancer cells. It is a type of immunostimulant.

Display Name: Mifamurtide

Label: Mifamurtide

NCI Thesaurus Code: C1394 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0129341  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CGP 19835A Lipid
Junovan
L-MTP-PE
MEPACT
Mepact
Mifamurtide
MIFAMURTIDE
mifamurtide
MTP-PE Liposome
muramyl tripeptide phosphatidylethanolamine
Muramyl Tripeptide Phosphatidylethanolamine Liposome

External Source Codes: 
CAS Registry Number 838853-48-8 (see NLM ChemIDplus info)
FDA UNII Code 1LM890Q4FY
NSC Code 628280 (see NCI DTP info)
PDQ Closed Trial Search ID 41541
PDQ Open Trial Search ID 41541 (check for NCI PDQ open clinical trial info)
UMLS CUI C0129341

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C59H108N6O19P.Na.H2O
code C1394
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Muramyl_Tripeptide_Phosphatidylethanolamine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1394

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