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Version: 17.06d (Release date: 2017-06-26)
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Menogaril (Code C1389)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Menogaril

Definition: A semisynthetic derivative of the anthracycline antineoplastic antibiotic nogalamycin. Menogaril intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin. (NCI04)

Label: Menogaril

NCI Thesaurus Code: C1389 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0127527  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
7(R)-O-Methylnogarol
7-(R)-O-methylnogarol
7-con-O-Methylnogarol
7-con-O-methylnogarol
7-con-O-methylnorgarol
7-OMEN
[2R-(2alpha,3beta,4alpha,5beta,6alpha,11alpha,13alpha)]-4-(dimethylamino)-3,4,5,6,11,12,13,14-octahydro-3,5,8,10,13-pentahydroxy-11-methoxy-6,13-dimethyl-2,6-epoxy-2H-naphthaceno[1,2-b]oxocin-9,16-dione
MEN
MENOGARIL
Menogaril
Menogarol
OMEN,7-
TUT-7
U-52047

External Source Codes: 
CAS Registry Number 71628-96-1 (see NLM ChemIDplus info)
FDA UNII Code 8JSV4O30HQ
NSC Code 269148 (see NCI DTP info)
PDQ Closed Trial Search ID 40153
PDQ Open Trial Search ID 40153 (check for NCI PDQ open clinical trial info)
UMLS CUI C0127527

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C28H31NO10
code C1389
Contributing_Source FDA
Legacy_Concept_Name Menogaril
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1389

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