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Version: 17.06d (Release date: 2017-06-26)
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Liposomal NDDP (Code C1383)

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Terms & Properties

Preferred Name: Liposomal NDDP

Definition: A synthetic liposomal formulation of bis-neodecanoate diaminocyclohexane platinum (NDDP), a third-generation platinum complex analogue of cisplatin, with potential antineoplastic activity. After displacement of the 2 long-chain aliphatic leaving groups (neodecanoic acid), platinum diaminocyclohexane (DACH) complexes become highly reactive and alkylate macromolecules, forming both inter- and intra-stranded DNA cross-linkings and inhibiting DNA synthesis, which results in tumor cell cytotoxicity. Because DNA mismatch-repair (MMR) complexes do not recognize DACH-platinum adducts, DNA repair mechanisms are inhibited, overcoming limitations observed with other platinum-based agents. In addition, the liposomal encapsulation improves the bioavailability of NDDP and reduces its toxicity profile.

Label: Liposomal NDDP

NCI Thesaurus Code: C1383 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0125061  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Aroplatin
L-NDDP
Liposomal-Cisplatin Analogue
Liposomal-Entrapped Cis-Bis-Neodecanoate-trans-R,R-1,2-Diaminocyclohexane Platinum (II)
Liposomal NDDP
Liposomal Neodecanoic Acid Platinum Complex

External Source Codes: 
CAS Registry Number 114488-24-3 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 43010
PDQ Open Trial Search ID 43010 (check for NCI PDQ open clinical trial info)
UMLS CUI C0125061

Other Properties:
     Name Value (qualifiers indented underneath)
code C1383
Legacy_Concept_Name Liposomal-Cisplatin_Analogue
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1383

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