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Version: 17.06d (Release date: 2017-06-26)
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Irinotecan Hydrochloride (Code C1381)

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Terms & Properties

Preferred Name: Irinotecan Hydrochloride

Definition: The hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.

NCI-GLOSS Definition: A drug used alone or with other drugs to treat colon cancer or rectal cancer that has spread to other parts of the body or has come back after treatment with fluorouracil. It is also being studied in the treatment of other types of cancer. Camptosar blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of topoisomerase inhibitor and a type of camptothecin analog.

Display Name: Irinotecan Hydrochloride

Label: Irinotecan Hydrochloride

NCI Thesaurus Code: C1381 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0594375  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Camptothecin 11
CPT 11
Irinotecan Hydrochloride
irinotecan hydrochloride

External Source Codes: 
CAS Registry Number 136572-09-3 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 41714
PDQ Open Trial Search ID 41714 (check for NCI PDQ open clinical trial info)
UMLS CUI C0594375

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For State IVB Cervical cancer; Colorectal cancer; Esophageal cancer; Gastric cancer; Non-small cell lung cancer; Small cell lung cancer
Chemical_Formula C33H38N4O6.HCl.3H2O
code C1381
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Irinotecan
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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