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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Interleukin-12 (Code C1380)

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Terms & Properties

Preferred Name: Recombinant Interleukin-12

Definition: A recombinant form of the endogenous heterodimeric cytokine interleukin-12 with potential antineoplastic activity. Recombinant interleukin-12 binds to and activates its cell-surface receptor, stimulating the production of interferon-gamma (IFN) which, in turn, induces IFN-gamma-inducible protein-10 (IP-10) and so inhibits tumor angiogenesis. (NCI04)

NCI-GLOSS Definition: One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-12 is made mainly by B lymphocytes and macrophages. It causes other immune cells to make cytokines and increases the growth of T lymphocytes. It may also block the growth of new blood vessels. Interleukin-12 made in the laboratory is used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-12 is a type of cytokine.

Display Name: Recombinant Interleukin-12

Label: Recombinant Interleukin-12

NCI Thesaurus Code: C1380 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1524115  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cytotoxic Lymphocyte Maturation Factor
IL-12
interleukin-12
Interleukin-12
Interleukin 12
Natural Killer Cell Stimulatory Factor
NM-IL-12
Recombinant human interleukin-12 (IL-12) cytokine
Recombinant Interleukin-12
Ro 24-7472

External Source Codes: 
CAS Registry Number 187348-17-0 (see NLM ChemIDplus info)
NSC Code 672423 (see NCI DTP info)
PDQ Closed Trial Search ID 42153
PDQ Open Trial Search ID 42153 (check for NCI PDQ open clinical trial info)
UMLS CUI C1524115

Other Properties:
     Name Value (qualifiers indented underneath)
code C1380
Contributing_Source CTRP
Legacy_Concept_Name Therapeutic_Interleukin-12
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1380

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