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Version: 17.08d (Release date: 2017-08-28)
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Fulvestrant (Code C1379)

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Terms & Properties

Preferred Name: Fulvestrant

Definition: A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. (NCI04)

NCI-GLOSS Definition: A drug used to treat certain types of breast cancer in postmenopausal women. It is also being studied in the treatment of other types of cancer. Faslodex blocks estrogen activity in the body and is a type of antiestrogen.

Display Name: Fulvestrant

Label: Fulvestrant

NCI Thesaurus Code: C1379 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0935916  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Faslodex(ICI 182,780)
ICI 182,780
ICI 182780

External Source Codes: 
CAS Registry Number 129453-61-8 (see NLM ChemIDplus info)
FDA UNII Code 22X328QOC4
ChEBI ID CHEBI:31638 (see ChEBI info)
NSC Code 719276 (see NCI DTP info)
PDQ Closed Trial Search ID 43053
PDQ Open Trial Search ID 43053 (check for NCI PDQ open clinical trial info)
UMLS CUI C0935916

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Hormone receptor-positive metastatic breast cancer
Chemical_Formula C32H47F5O3S
code C1379
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Fulvestrant
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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