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Version: 17.06d (Release date: 2017-06-26)
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Hematoporphyrin Derivative (Code C1377)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Hematoporphyrin Derivative

Definition: A complex mixture of monomeric and aggregated porphyrins with photosensitizing activity. Upon systemic administration, hematoporphyrin derivatives accumulate in tumor cells and, once activated by red laser light (630 nm), in the presence of oxygen, produce singlet oxygen and other reactive oxygen radicals, resulting in local radical-mediated tumor cell death.

NCI-GLOSS Definition: A drug used in photodynamic therapy that is absorbed by tumor cells. When exposed to light, it becomes active and kills the cancer cells.

Label: Hematoporphyrin Derivative

NCI Thesaurus Code: C1377 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0121300  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
hematoporphyrin derivative
Hematoporphyrin derivative
Hematoporphyrin Derivative
HPD
photofrin
Photofrin

External Source Codes: 
CAS Registry Number 68335-15-9 (see NLM ChemIDplus info)
NSC Code 265328 (see NCI DTP info)
PDQ Closed Trial Search ID 40859
PDQ Open Trial Search ID 40859 (check for NCI PDQ open clinical trial info)
UMLS CUI C0121300

Other Properties:
     Name Value (qualifiers indented underneath)
code C1377
Legacy_Concept_Name Hematoporphyrin_Derivative
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1377

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