|Hematoporphyrin Derivative (Code C1377)|
|Terms & Properties|
Preferred Name: Hematoporphyrin Derivative
Definition: A complex mixture of monomeric and aggregated porphyrins with photosensitizing activity. Upon systemic administration, hematoporphyrin derivatives accumulate in tumor cells and, once activated by red laser light (630 nm), in the presence of oxygen, produce singlet oxygen and other reactive oxygen radicals, resulting in local radical-mediated tumor cell death.
NCI-GLOSS Definition: A drug used in photodynamic therapy that is absorbed by tumor cells. When exposed to light, it becomes active and kills the cancer cells.
Label: Hematoporphyrin Derivative
NCI Metathesaurus Link: C0121300 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|CAS Registry Number||68335-15-9 (see NLM ChemIDplus info)|
|NSC Code||265328 (see NCI DTP info)|
|PDQ Closed Trial Search ID||40859|
|PDQ Open Trial Search ID||40859 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|