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Version: 17.06d (Release date: 2017-06-26)
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Fostriecin (Code C1372)

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Terms & Properties

Preferred Name: Fostriecin

Definition: An anti-tumor antibiotic isolated from the bacterium Streptomyces pulveraceus. Fostriecin inhibits topoisomerase II catalytic activity, resulting in impaired DNA and RNA synthesis in various malignant cell types. This agent also inhibits serine/threonine protein phosphatase type 2A in some tumor cell types, thereby interfering with cellular proliferation and differentiation. (NCI04)

Label: Fostriecin

NCI Thesaurus Code: C1372 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0118175  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2H-pyran-2-one,5,6-dihydro-6-(3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11,-tridecatetraenyl)-,trans
Fostriecin
FOSTRIECIN
FST
Phosphotrienin

External Source Codes: 
CAS Registry Number 87810-56-8 (see NLM ChemIDplus info)
FDA UNII Code ZO1648L551
NSC Code 339638 (see NCI DTP info)
PDQ Closed Trial Search ID 41703
PDQ Open Trial Search ID 41703 (check for NCI PDQ open clinical trial info)
UMLS CUI C0118175

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H27O9P
code C1372
Contributing_Source FDA
Legacy_Concept_Name Fostriecin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1372

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