Terms & Properties

Preferred Name:  Teclistamab

Definition:  A bispecific humanized monoclonal antibody against human CD3, a T-cell surface antigen, and human B-cell maturation antigen (BCMA; TNFRSF17), a tumor-associated antigen (TAA) expressed on plasma cells, with potential antineoplastic activity. Upon administration, teclistamab binds to both CD3 on T-cells and BCMA expressed on malignant plasma cells. This results in the cross-linking of T-cells and tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against BCMA-expressing plasma cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival.

Display Name:  Teclistamab

Label:  Teclistamab

NCI Thesaurus Code:  C136823 (Search for linked caDSR metadata)   (search value sets)

NCI Metathesaurus Link:  CL524654  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

JNJ 64007957

JNJ-64007957

JNJ64007957

Teclistamab

TECLISTAMAB

Teclistamab-cqyv

Tecvayli

External Source Codes: 

CAS Registry Number	2119595-80-9 (see NLM ChemIDplus info)
NCI Drug Dictionary ID	789710 (see NCI Drug Dictionary info)
FDA UNII Code	54534MX6Z9
PDQ Closed Trial Search ID	789710
PDQ Open Trial Search ID	789710
NCI META CUI	CL524654

Other Properties:

Name	Value (qualifiers indented underneath)
code	C136823
Contributing_Source	CTRP
Contributing_Source	FDA
Contributing_Source	GDC
Contributing_Source	HemOnc
Maps_To	Anti-CD3/Anti-BCMA Bispecific Monoclonal Antibody JNJ-64007957
	Target_Terminology: GDC       Relationship_to_Target: Has Synonym       Target_Term_Type: PT       Target_Code: therapeutic_agents
Maps_To	Teclistamab
	Target_Terminology: GDC       Relationship_to_Target: Has Synonym       Target_Term_Type: PT       Target_Code: therapeutic_agents
Semantic_Type	Pharmacologic Substance

Additional Concept Data: 

Defined Fully by Roles: No

URL:https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C136823