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Version: 17.06d (Release date: 2017-06-26)
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Elliptinium Acetate (Code C1367)

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Terms & Properties

Preferred Name: Elliptinium Acetate

Definition: Acetate salt of elliptinium, a derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis.

Label: Elliptinium Acetate

NCI Thesaurus Code: C1367 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0100593  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6H-Pyrido[4, 3-b]carbazolium, 9-hydroxy-2,5,11-trimethyl-acetate (salt)
9-Hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium Acetate (Salt)
9-Hydroxy-2-methylellipticinium acetate
9-Hydroxy-2-methylellipticinium Acetate
Celiptium
ELLIPTINIUM ACETATE
Elliptinium Acetate
N-2-Methyl-9-hydroxyellipticinium Acetate

External Source Codes: 
CAS Registry Number 58337-35-2 (see NLM ChemIDplus info)
FDA UNII Code H9B41234P4
NSC Code 264137 (see NCI DTP info)
PDQ Closed Trial Search ID 39231
PDQ Open Trial Search ID 39231 (check for NCI PDQ open clinical trial info)
UMLS CUI C0100593

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H17N2O.C2H3O2
code C1367
Contributing_Source FDA
Legacy_Concept_Name Elliptinium
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1367

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