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Version: 17.12d (Release date: 2017-12-26)
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Dimesna (Code C1365)

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Terms & Properties

Preferred Name: Dimesna

Definition: A synthetic derivative of dithio-ethane sulfonate with uroprotective properties. In the kidney, dimesna undergoes reduction to the free thiol compound, mesna, which reacts chemically with the urotoxic ifosfamide metabolites acrolein and 4-hydroxy-ifosfamide, resulting in their detoxification. This agent also inhibits cyclophosphamide-induced hemorrhagic cystitis.

NCI-GLOSS Definition: A drug that belongs to the family of drugs called chemoprotective agents.

Display Name: Dimesna

Label: Dimesna

NCI Thesaurus Code: C1365 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0114346  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2,2'-Dithio-bis-ethanesulfonate, Disodium Salt
2,2'-Dithiobisethanesulfonic Acid, Disodium Salt
Mesna Disulfide

External Source Codes: 
CAS Registry Number 16208-51-8 (see NLM ChemIDplus info)
FDA UNII Code 230R951Y4D
NSC Code 716976 (see NCI DTP info)
PDQ Closed Trial Search ID 43236
PDQ Open Trial Search ID 43236 (check for NCI PDQ open clinical trial info)
UMLS CUI C0114346

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Ifosfamide-induced hemorrhagic cystitis, prophylaxis
Chemical_Formula C4H8O6S4.2Na
code C1365
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Dimesna
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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