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Version: 16.11d (Release date: 2016-11-28)
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Didemnin B (Code C1364)

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Terms & Properties

Preferred Name: Didemnin B

Definition: A cyclic depsipeptide extracted from the Caribbean tunicate Trididemnum cyanophorum. Didemnin B activates caspase, thereby inducing apoptosis, and prevents eukaryotic elongation factor 2 (eEF-2)-dependent translocation, thereby inhibiting protein synthesis. This agent also has immunosuppressive and antiviral properties. (NCI04)

Label: Didemnin B

NCI Thesaurus Code: C1364 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0113768  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
15H-Pyrrolol[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotri-cosine, Cyclic Peptide Deriv. (9CI)
Didemnin
Didemnin B
L-Tyrosine, N-[1-[N-[4-[[3-Hydroxy-4-[[N-[N-[1-(2-hydroxy-1-oxopropyl)- L-prolyl]-N-methyl-L-leucyl]-L-threonyl]amino]-5-methyl-1-oxoheptyl]oxy]-2,5-dimethyl-1,3-dioxohexyl]-L-leucyl]- L-prolyl]-N,O-dimethyl-, phi-lactone (9CI)

External Source Codes: 
CAS Registry Number 77327-05-0 (see NLM ChemIDplus info)
NSC Code 325319 (see NCI DTP info)
NSC Code 333841 (see NCI DTP info)
PDQ Closed Trial Search ID 39974
PDQ Open Trial Search ID 39974 (check for NCI PDQ open clinical trial info)
UMLS CUI C0113768

Other Properties:
Name Value (qualifiers indented underneath)
code C1364
Legacy_Concept_Name Didemnin_B
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1364

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