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Version: 17.06d (Release date: 2017-06-26)
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Diaziquone (Code C1363)

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Terms & Properties

Preferred Name: Diaziquone

Definition: A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase (DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the 5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting tumor cell proliferation. DTD is over-expressed in many tumors relative to normal tissue, including lung, colon, breast and liver tumors.

NCI-GLOSS Definition: An anticancer drug that is able to cross the blood-brain barrier and kill cancer cells in the central nervous system.

Label: Diaziquone

NCI Thesaurus Code: C1363 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0113600  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,4-cyclohexadiene-1,4-dicarbamic acid,2,5-bis(1-aziridinyl)-3,6-dioxo,-diethyl ester
1,4-cyclohexadiene-1,4-dicarbamic acid, 2, 5-bis(1-aziridinyl)-3,6-dioxo-, diethyl ester
1,4-Cyclohexadiene-1,4-dicarbamic acid, 2, 5-bis(1-aziridinyl)-3,6-dioxo-, diethyl ester
2,5-bis(1-aciridinyl)-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone
2,5-bis(1-aziridinyl)-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone
2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-dicarbamic acid diethyl ester
2,5-diaziridinyl-3,6-bis(ethoxycarbonyl-amino)-1,4-benzoquinone
[2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-diyl]biscarbamic acid diethyl ester
Aziridinylbenzoquinone
Aziridinylbenzoquinone carbamic acid
Aziridinyl Benzoquinone
AZQ
Carbamic acid, [2,5-bis(1-aziridinyl)-3,6-dioxo-1, 4-cyclohexadiene-1,4-diyl]bis-, diethyl ester (9CI)
carbamic acid, [2,5-bis(1-aziridinyl)-3,6-dioxo-1, 4-cyclohexadiene-1,4-diyl]bis-, diethyl ester (9CI)
CI-904
Diaziquone
DIAZIQUONE
diaziquone

External Source Codes: 
CAS Registry Number 57998-68-2 (see NLM ChemIDplus info)
FDA UNII Code FQL5EUP13W
NSC Code 182986 (see NCI DTP info)
PDQ Closed Trial Search ID 39161
PDQ Open Trial Search ID 39161 (check for NCI PDQ open clinical trial info)
UMLS CUI C0113600

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C16H20N4O6
code C1363
Contributing_Source FDA
Legacy_Concept_Name Diaziquone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1363

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