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Version: 16.10e (Release date: 2016-10-31)
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Granisetron Hydrochloride (Code C1353)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Granisetron Hydrochloride

Definition: The hydrochloride salt of an indazole derivative with antiemetic properties. As a selective serotonin receptor antagonist, granisetron competitively blocks the action of serotonin at 5-hydroxytryptamine3 (5-HT3) receptors, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.

NCI-GLOSS Definition: A drug used to treat nausea and vomiting caused by cancer treatment. It is a type of serotonin receptor antagonist and a type of antiemetic.

Display Name: Granisetron Hydrochloride

Label: Granisetron Hydrochloride

NCI Thesaurus Code: C1353 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0543476  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Endo-N-(9-methyl-9-azabicyclo [3.3.1] non-3-yl)-1-methyl-1H-indazole-3-carboxamide Hydrochloride
Granisetron Hydrochloride
GRANISETRON HYDROCHLORIDE
granisetron hydrochloride
Kytril

External Source Codes: 
CAS Registry Number 107007-99-8 (see NLM ChemIDplus info)
FDA UNII Code 318F6L70J8
NSC Code 672814 (see NCI DTP info)
PDQ Closed Trial Search ID 42236
PDQ Open Trial Search ID 42236 (check for NCI PDQ open clinical trial info)
UMLS CUI C0543476

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chemotherapy- and postoperative-induced nausea and vomiting, treatment and prophylaxis
Chemical_Formula C18H24N4O.HCl
code C1353
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Granisetron
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1353

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