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Version: 17.08d (Release date: 2017-08-28)
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Beta-Thioguanine Deoxyriboside (Code C1350)

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Terms & Properties

Preferred Name: Beta-Thioguanine Deoxyriboside

Definition: A thiopurine nucleoside derivative with antineoplastic activity. After conversion to the triphosphate, beta-thioguanine deoxyriboside is incorporated into DNA, resulting in inhibition of DNA replication. This agent is cytotoxic against leukemia cell lines and has demonstrated some activity against leukemia cells in vivo. Beta-thioguanine deoxyriboside demonstrates antineoplastic activity against 6-thioguanine-resistant tumor cells. (NCI04)

Label: Beta-Thioguanine Deoxyriboside

NCI Thesaurus Code: C1350 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0053376  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
.beta.-2'-Deoxythiol guanosine
.beta.-Thioguanine deoxyriboside
1,9-dihydro-6H-purine-6-thione, 2-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)
6H-Purine-6-thione, 2-amino-9-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-1,9-dihydro-
9H-Purine-6-thiol, 2-amino-9-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-, monohydrate
9H-purine-6-thiol, 2-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl) monohydrate
beta-2'-deoxythiol guanosine
Beta-Thioguanine Deoxyriboside
Beta Thioguanine Deoxyriboside
thioguanine 9-beta-D-2'-deoxyriboside
Thioguanine 9.beta.D-2'-deoxyriboside

External Source Codes: 
CAS Registry Number 789-61-7 (see NLM ChemIDplus info)
CAS Registry Number 64039-27-6 (see NLM ChemIDplus info)
NSC Code 71261 (see NCI DTP info)
PDQ Closed Trial Search ID 39711
PDQ Open Trial Search ID 39711 (check for NCI PDQ open clinical trial info)
UMLS CUI C0053376

Other Properties:
     Name Value (qualifiers indented underneath)
code C1350
Legacy_Concept_Name Beta-Thioguanine_Deoxyriboside
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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