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Version: 17.06d (Release date: 2017-06-26)
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Pamidronate Disodium (Code C1345)

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Terms & Properties

Preferred Name: Pamidronate Disodium

Definition: The disodium salt of the synthetic bisphosphonate pamidronate. Although its mechanism of action is not completely understood, pamidronate appears to adsorb to calcium phosphate crystals in bone, blocking their dissolution by inhibiting osteoclast-mediated bone resorption. This agent does not inhibit bone mineralization and formation.

Display Name: Pamidronate Disodium

Label: Pamidronate Disodium

NCI Thesaurus Code: C1345 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0356588  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Aminomux
Aredia
GCP-23339A
Pamidronate Disodium
PAMIDRONATE DISODIUM

External Source Codes: 
CAS Registry Number 109552-15-0 (see NLM ChemIDplus info)
FDA UNII Code 8742T8ZQZA
NSC Code 720699 (see NCI DTP info)
PDQ Closed Trial Search ID 39149
PDQ Open Trial Search ID 39149 (check for NCI PDQ open clinical trial info)
UMLS CUI C0356588

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Hypercalcemia of malignancy; Osteolytic bone lesions of multiple myeloma; Osteolytic bone metastases of breast cancer; Pagets disease
Chemical_Formula C3H9NO7P2.2Na.5H2O
code C1345
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Pamidronate_Disodium
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1345

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