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Version: 17.12d (Release date: 2017-12-26)
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Valrubicin (Code C1340)

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Terms & Properties

Preferred Name: Valrubicin

Definition: A semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. With a mechanism of action that appears to differ from doxorubicin, valrubicin is converted intracytoplasmically into N-trifluoroacetyladriamycin, which interacts with topoisomerase II, stabilizing the complex between the enzyme and DNA; consequently, DNA replication and repair and RNA and protein synthesis are inhibited and the cell cycle is arrested in the G2 phase. In addition, this agent accumulates in the cell cytoplasm where it inhibits protein kinase C (PKC). Valrubicin is less cardiotoxic than doxorubicin when administered systemically; applied topically, this agent shows excellent tissue penetration. Structurally, the trifluoro-acetyl moiety on the amino group of the glycoside and the valerate moiety appear to result in a lipophilicity that is greater than of doxorubicin, resulting in increased intracytoplasmic concentrations.

NCI-GLOSS Definition: A drug used to treat bladder cancer that does not respond to BCG (Bacillus Calmette Guerin). It is an anthracycline and is a type of antitumor antibiotic.

Display Name: Valrubicin

Label: Valrubicin

NCI Thesaurus Code: C1340 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0068314  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AD 32

External Source Codes: 
CAS Registry Number 56124-62-0 (see NLM ChemIDplus info)
FDA UNII Code 2C6NUM6878
NSC Code 246131 (see NCI DTP info)
PDQ Closed Trial Search ID 39135
PDQ Open Trial Search ID 39135 (check for NCI PDQ open clinical trial info)
UMLS CUI C0068314

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C34H36F3NO13
code C1340
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Valrubicin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  


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