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Version: 17.06d (Release date: 2017-06-26)
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Cevimeline Hydrochloride (Code C1337)

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Terms & Properties

Preferred Name: Cevimeline Hydrochloride

Definition: A cholinergic analogue with glandular secretion stimulatory activity. Cevimeline binds to and activates muscarinic receptors, thereby increasing the secretions in exocrine salivary and sweat glands. This cholinergic agonist also increases the tone of smooth muscle in the gastrointestinal and urinary tracts. Cevimeline is being studied as a treatment for dry mouth caused by radiation therapy to the head and neck.

NCI-GLOSS Definition: A drug used to treat certain disorders of the salivary gland. It is also being studied as a treatment for dry mouth caused by radiation therapy to the head and neck. It increases the amount of saliva and sweat made by saliva and sweat glands. Cevimeline hydrochloride is a type of cholinergic agonist.

Display Name: Cevimeline Hydrochloride

Label: Cevimeline Hydrochloride

NCI Thesaurus Code: C1337 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0874063  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AF-102B
Cevimeline Hydrochloride
cevimeline hydrochloride
CEVIMELINE HYDROCHLORIDE
Evoxac

External Source Codes: 
CAS Registry Number 153504-70-2 (see NLM ChemIDplus info)
FDA UNII Code P81Q6V85NP
PDQ Closed Trial Search ID 38315
PDQ Open Trial Search ID 38315 (check for NCI PDQ open clinical trial info)
UMLS CUI C0874063

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Sjogrens syndrome
Chemical_Formula 2C10H17NOS.2HCl.H2O
code C1337
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Cevimeline
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1337

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