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Version: 17.06d (Release date: 2017-06-26)
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Cladribine (Code C1336)

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Terms & Properties

Preferred Name: Cladribine

Definition: A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called antimetabolites.

Display Name: Cladribine

Label: Cladribine

NCI Thesaurus Code: C1336 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0092801  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-CdA
2-Chloro-2-Deoxyadenosine
2-Chlorodeoxyadenosine
2CDA
CdA
Cladribina
Cladribine
CLADRIBINE
cladribine
Leustat
Leustatin
Leustatine
RWJ-26251

External Source Codes: 
CAS Registry Number 4291-63-8 (see NLM ChemIDplus info)
FDA UNII Code 47M74X9YT5
ChEBI ID CHEBI:567361 (see ChEBI info)
NSC Code 105014 (see NCI DTP info)
NSC Code 105014-F (see NCI DTP info)
PDQ Closed Trial Search ID 41184
PDQ Open Trial Search ID 41184 (check for NCI PDQ open clinical trial info)
UMLS CUI C0092801

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acute myeloid leukemia; Chronic lymphocytic leukemia; Cutaneous T-cell lymphoma; Hairy cell leukemia; Langerhans cell histiocytosis; Non-Hodgkins lymphoma; Waldenstroms macroglobulinemia
Chemical_Formula C10H12ClN5O3
code C1336
Contributing_Source CTRP
Contributing_Source FDA
DesignNote http://www.cancercare.on.ca/pdfdrugs/Cladribi.pdf
Legacy_Concept_Name Cladribine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1336

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