Terms & Properties

Preferred Name:  Niraparib Tosylate Monohydrate

Definition:  An orally bioavailable, hydrated, tosylate salt form of niraparib, an inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks.

Label:  Niraparib Tosylate Monohydrate

NCI Thesaurus Code:  C133238 (Search for linked caDSR metadata)   (search value sets)

NCI Metathesaurus Link:  CL520459  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

2H-Indazole-7-carboxamide, 2-(4-(3S)-3-piperidinylphenyl)-, 4-Methylbenzenesulfonate, Hydrate (1:1:1)

NIRAPARIB TOSYLATE MONOHYDRATE

Niraparib Tosylate Monohydrate

Zejula

External Source Codes: 

CAS Registry Number	1613220-15-7 (see NLM ChemIDplus info)
NCI Drug Dictionary ID	615263 (see NCI Drug Dictionary info)
FDA UNII Code	195Q483UZD
PDQ Closed Trial Search ID	615263
PDQ Open Trial Search ID	615263
NCI META CUI	CL520459

Other Properties:

Name	Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For	maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer
code	C133238
Contributing_Source	FDA
Contributing_Source	GDC
Maps_To	Niraparib Tosylate Monohydrate
	Target_Terminology: GDC       Relationship_to_Target: Has Synonym       Target_Term_Type: PT       Target_Code: therapeutic_agents
Semantic_Type	Pharmacologic Substance

Additional Concept Data: 

Defined Fully by Roles: No

URL:https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C133238