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Version: 16.11d (Release date: 2016-11-28)
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Doxorubicin Hydrochloride (Code C1326)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Doxorubicin Hydrochloride

Definition: The hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.

NCI-GLOSS Definition: A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. Adriamycin PFS comes from the bacterium Streptomyces peucetius. It damages DNA and may kill cancer cells. It is a type of anthracycline antitumor antibiotic.

Display Name: Doxorubicin Hydrochloride

Label: Doxorubicin Hydrochloride

NCI Thesaurus Code: C1326 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0085752  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
14-Hydroxydaunorubicin Hydrochloride
3-Hydroxyacetyldaunorubicin Hydrochloride
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S-cis)-(9CI)
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI)
ADM
Adriacin
Adriamycin
ADRIAMYCIN, HYDROCHLORIDE
Adriamycine
Adriamycin Hydrochloride
Adriamycin hydrochloride
Adriamycin PFS
Adriamycin RDF
Adriblastina
Adriblastine
Adrimedac
Chloridrato de Doxorrubicina
DOX
DOXO-CELL
Doxolem
Doxorubicin.HCl
Doxorubicin Hydrochloride
DOXORUBICIN HYDROCHLORIDE
Doxorubicin hydrochloride
doxorubicin hydrochloride
Doxorubin
Farmiblastina
FI-106
FI 106
hydroxydaunorubicin
L-Lyxo-hexopyranoside, 3b-glycol-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1a-naphthacenyl 3-amino-2,3,6-trideoxy-alpha-, hydrochloride
Rubex

External Source Codes: 
CAS Registry Number 25316-40-9 (see NLM ChemIDplus info)
FDA UNII Code 82F2G7BL4E
NSC Code 123127 (see NCI DTP info)
PDQ Closed Trial Search ID 38860
PDQ Open Trial Search ID 38860 (check for NCI PDQ open clinical trial info)
UMLS CUI C0085752

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Wilms' tumor; neuroblastoma; soft tissue and bone sarcomas; small cell carcinoma of the lung; lymphomas; multiple myeloma; mesotheliomas; germ cell tumors of the ovary or testis.
Accepted_Therapeutic_Use_For Carcinomas of breast, thyroid, gastric, ovarian, bronchogenic, head and neck, prostate, cervical, pancreatic, uterine, hepatic, and transitional cell bladder carcinomas.
Chemical_Formula C27H29NO11.HCl
code C1326
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Doxorubicin_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1326

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