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National Cancer Institute
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Version: 17.10e (Release date: 2017-10-30)
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Muromonab-CD3 (Code C1321)

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Terms & Properties

Preferred Name: Muromonab-CD3

Definition: A murine IgG2a monoclonal antibody with immunosuppressive activity. Muromonab-CD3 binds to and inhibits CD3 on the surface of circulating T-lymphocytes; binding of muromonab-CD3 to CD3-positive T cells results in an early activation of this T cell subset, followed by cytokine release, and subsequently inhibition of T cell functions. This agent may cause the opsonization and elimination of CD3-positive T cells from the circulation by mononuclear phagocytes in the liver and spleen. CD3 is part of the functional T cell receptor (TCR) complex, which is necessary for antigen recognition by T cells, and is required for signal transduction.

NCI-GLOSS Definition: A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.

Display Name: Muromonab-CD3

Label: Muromonab-CD3

NCI Thesaurus Code: C1321 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0085379  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-CD3 Monoclonal Antibody OKT3
Monoclonal Antibody OKT3
muromonab-CD3 monoclonal antibody
Orthoclone OKT3

External Source Codes: 
CAS Registry Number 140608-64-6 (see NLM ChemIDplus info)
NSC Code 618843 (see NCI DTP info)
PDQ Closed Trial Search ID 39580
PDQ Open Trial Search ID 39580 (check for NCI PDQ open clinical trial info)
UMLS CUI C0085379

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Allograft rejection
code C1321
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Monoclonal_Antibody_OKT3
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: Yes  


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