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Version: 17.06d (Release date: 2017-06-26)
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Leuprolide Acetate (Code C1319)

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Terms & Properties

Preferred Name: Leuprolide Acetate

Definition: The acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression.

NCI-GLOSS Definition: A drug used to treat symptoms of advanced prostate cancer. It is also being studied in the treatment of other conditions and types of cancer. The active ingredient leuprolide blocks the body from making testosterone (a male hormone) and estradiol (a female hormone). It may stop the growth of prostate cancer cells that need testosterone to grow. Some brands of leuprolide are also used to treat early puberty in children and certain gynecologic conditions. Leuprolide acetate is a type of gonadotropin-releasing hormone analog.

Display Name: Leuprolide Acetate

Label: Leuprolide Acetate

NCI Thesaurus Code: C1319 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700596  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-D-Leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor (Pig) Monoacetate
6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig) Monoacetate
A-43818
Abbott-43818
Abbott 43818
Carcinil
Depo-Eligard
Eligard
Enanton
Enantone
Enantone-Gyn
Ginecrin
LEUP
Leuplin
Leuprolide Acetate
LEUPROLIDE ACETATE
leuprolide acetate
Leuprorelin Acetate
Lucrin
Lucrin Depot
Lupron
Lupron Depot
Lupron Depot-3 Month
Lupron Depot-4 Month
Lupron Depot-Ped
Procren
Procrin
Prostap
TAP-144
Trenantone
Uno-Enantone
Viadur

External Source Codes: 
CAS Registry Number 74381-53-6 (see NLM ChemIDplus info)
FDA UNII Code 37JNS02E7V
ChEBI ID CHEBI:63597 (see ChEBI info)
NSC Code 377526 (see NCI DTP info)
PDQ Closed Trial Search ID 40058
PDQ Open Trial Search ID 40058 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700596

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Endometriosis; In-vitro fertilization; Precocious puberty; Premenstrual syndrome; Prostate cancer; Uterine fibroid tumors
Chemical_Formula C59H84N16O12.C2H4O2
code C1319
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Leuprolide
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1319

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