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Version: 17.06d (Release date: 2017-06-26)
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Lithium Carbonate (Code C1318)

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Terms & Properties

Preferred Name: Lithium Carbonate

Definition: The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stem cells.

Display Name: Lithium Carbonate

Label: Lithium Carbonate

NCI Thesaurus Code: C1318 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0085217  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Escalith
Eskalith
Lithane
Lithium
Lithium Carbonate
Lithium carbonate
LITHIUM CARBONATE
Lithobid
Lithonate
Lithotabs

External Source Codes: 
CAS Registry Number 554-13-2 (see NLM ChemIDplus info)
FDA UNII Code 2BMD2GNA4V
ChEBI ID CHEBI:6504 (see ChEBI info)
NSC Code 16895 (see NCI DTP info)
PDQ Closed Trial Search ID 39491
PDQ Open Trial Search ID 39491 (check for NCI PDQ open clinical trial info)
UMLS CUI C0085217

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula CO3.2Li
code C1318
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Lithium_Carbonate
Semantic_Type Inorganic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1318

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