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Version: 16.11d (Release date: 2016-11-28)
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Bupropion Hydrochloride (Code C1317)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Bupropion Hydrochloride

Definition: The hydrochloride salt of an aminoketone antidepressant. The molecular mechanism of the antidepressant effect of bupropion is unknown. This agent does not inhibit monoamine oxidase and, compared to classical tricyclic antidepressants, is a weak blocker of the neuronal uptake of serotonin and norepinephrine. Buproprion also weakly inhibits the neuronal re-uptake of dopamine.

Display Name: Bupropion Hydrochloride

Label: Bupropion Hydrochloride

NCI Thesaurus Code: C1317 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0085934  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(+-)-1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone Hydrochloride
Amfebutamone
Bupropion Hydrochloride
BUPROPION HYDROCHLORIDE
BW 323U66
Forfivo XL
Wellbutrin
Zyban

External Source Codes: 
CAS Registry Number 31677-93-7 (see NLM ChemIDplus info)
FDA UNII Code ZG7E5POY8O
NSC Code 315851 (see NCI DTP info)
PDQ Closed Trial Search ID 38567
PDQ Open Trial Search ID 38567 (check for NCI PDQ open clinical trial info)
UMLS CUI C0085934

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Depression; Smoking cessation
Chemical_Formula C13H18ClNO.HCl
code C1317
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Bupropion
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1317

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