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Version: 17.06d (Release date: 2017-06-26)
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Tacrolimus (Code C1311)

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Terms & Properties

Preferred Name: Tacrolimus

Definition: A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.

NCI-GLOSS Definition: A drug used to help reduce the risk of rejection by the body of organ and bone marrow transplants.

Display Name: Tacrolimus

Label: Tacrolimus

NCI Thesaurus Code: C1311 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0085149  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
FK 506
Fujimycin
Hecoria
Hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
Prograf
Protopic
Tacrolimus
TACROLIMUS
tacrolimus

External Source Codes: 
CAS Registry Number 109581-93-3 (see NLM ChemIDplus info)
FDA UNII Code WM0HAQ4WNM
ChEBI ID CHEBI:61057 (see ChEBI info)
NSC Code 717865 (see NCI DTP info)
PDQ Closed Trial Search ID 42009
PDQ Open Trial Search ID 42009 (check for NCI PDQ open clinical trial info)
UMLS CUI C0085149

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Atopic dermatitis; Kidney transplant rejection, prophylaxis; Liver transplant rejection, prophylaxis
Chemical_Formula C44H69NO12.H2O
code C1311
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Tacrolimus
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1311

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