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Version: 16.11d (Release date: 2016-11-28)
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O6-Benzylguanine (Code C1306)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: O6-Benzylguanine

Definition: A guanine analogue with antineoplastic activity. O6-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair. Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA. (NCI04)

NCI-GLOSS Definition: A drug that may improve the response of cancer cells to chemotherapy.

Display Name: O6-Benzylguanine

Label: O6-Benzylguanine

NCI Thesaurus Code: C1306 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0083812  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-amino-6-(benzyloxy)purine
2-amino-6-(phenylmethoxy)-9h-purine
6-O-BENZYLGUANINE
6-O-Benzylguanine
O(6)-Benzylguanine
O(6)-benzylguanine
O-6-Benzylguanine
O6-Benzylguanine

External Source Codes: 
CAS Registry Number 19916-73-5 (see NLM ChemIDplus info)
FDA UNII Code 01KC87F8FE
NSC Code 637037 (see NCI DTP info)
PDQ Closed Trial Search ID 42113
PDQ Open Trial Search ID 42113 (check for NCI PDQ open clinical trial info)
UMLS CUI C0083812

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C12H11N5O
code C1306
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name O_6_Benzylguanine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1306

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