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Version: 17.06d (Release date: 2017-06-26)
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Oprelvekin (Code C1303)

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Terms & Properties

Preferred Name: Oprelvekin

Definition: A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin 11 (IL-11). Secreted by bone marrow stromal cells and a number of mesenchymal cells, IL-11 binds to and activates its cell-surface receptor, promoting primary and secondary immune responses, modulating antigen-specific antibody reactions, and preventing apoptotic cell death. This agent also stimulates the T-cell-dependent development of IgG-secreting B-cells in spleen cell cultures and may be an important regulator of megakaryocytopoiesis. (NCI04)

NCI-GLOSS Definition: A drug used to increase the number of blood cells, especially platelets, in some cancer patients receiving chemotherapy. Neumega is a form of interleukin-11 (a cytokine normally made by support cells in the bone marrow) that is made in the laboratory. It is a type of biological response modifier.

Display Name: Oprelvekin

Label: Oprelvekin

NCI Thesaurus Code: C1303 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0537670  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Adipogenesis Inhibitory Factor
IL-11
Interleukin-11
Interleukin-11-Recombinant
Interleukin 11
Neumega
Oprelvekin
OPRELVEKIN
oprelvekin
recombinant human interleukin-11
Recombinant Human Interleukin-11
Recombinant Interleukin-11
rhIL-11

External Source Codes: 
CAS Registry Number 145941-26-0 (see NLM ChemIDplus info)
FDA UNII Code HM5641GA6F
PDQ Closed Trial Search ID 42365
PDQ Open Trial Search ID 42365 (check for NCI PDQ open clinical trial info)
UMLS CUI C0537670

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chemotherapy-related thrombocytopenia
code C1303
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Therapeutic_Interleukin-11
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1303

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