skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Oprelvekin (Code C1303)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Oprelvekin

Definition: A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin 11 (IL-11). Secreted by bone marrow stromal cells and a number of mesenchymal cells, IL-11 binds to and activates its cell-surface receptor, promoting primary and secondary immune responses, modulating antigen-specific antibody reactions, and preventing apoptotic cell death. This agent also stimulates the T-cell-dependent development of IgG-secreting B-cells in spleen cell cultures and may be an important regulator of megakaryocytopoiesis. (NCI04)

NCI-GLOSS Definition: A drug used to increase the number of blood cells, especially platelets, in some cancer patients receiving chemotherapy. Neumega is a form of interleukin-11 (a cytokine normally made by support cells in the bone marrow) that is made in the laboratory. It is a type of biological response modifier.

Display Name: Oprelvekin

Label: Oprelvekin

NCI Thesaurus Code: C1303 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0537670  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Adipogenesis Inhibitory Factor
Interleukin 11
recombinant human interleukin-11
Recombinant Human Interleukin-11
Recombinant Interleukin-11

External Source Codes: 
CAS Registry Number 145941-26-0 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 42365
PDQ Open Trial Search ID 42365 (check for NCI PDQ open clinical trial info)
UMLS CUI C0537670

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chemotherapy-related thrombocytopenia
code C1303
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Therapeutic_Interleukin-11
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom