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Version: 17.06d (Release date: 2017-06-26)
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Dolastatin 10 (Code C1300)

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Terms & Properties

Preferred Name: Dolastatin 10

Definition: A pentapeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Binding to tubulin, Dolastatin 10 inhibits microtubule assembly, resulting in the formation of tubulin aggregates and inhibition of mitosis. This agent also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It binds to a protein that cells need to divide and it may kill cancer cells. Dolastatin 10 comes from a marine organism. It is a type of mitotic inhibitor.

Display Name: Dolastatin 10

Label: Dolastatin 10

NCI Thesaurus Code: C1300 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0082338  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
B720389K560
Dolastatin-10
Dolastatin 10
dolastatin 10
L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]]

External Source Codes: 
CAS Registry Number 110417-88-4 (see NLM ChemIDplus info)
NSC Code 376128 (see NCI DTP info)
PDQ Closed Trial Search ID 42316
PDQ Open Trial Search ID 42316 (check for NCI PDQ open clinical trial info)
UMLS CUI C0082338

Other Properties:
     Name Value (qualifiers indented underneath)
code C1300
Contributing_Source CTRP
Legacy_Concept_Name Dolastatin_10
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1300

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