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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Macrophage Colony-Stimulating Factor (Code C1290)

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Terms & Properties

Preferred Name: Recombinant Macrophage Colony-Stimulating Factor

Definition: A recombinant therapeutic agent which is chemically identical to or similar to the endogenous protein cytokine macrophage colony-stimulating factor (M-CSF). Synthesized endogenously by mesenchymal cells, M-CSF stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series and can reverse treatment-related neutropenias. Recombinant M-CSF may also enhance antigen presentation and activate antitumoral cytotoxic T-cells.

Label: Recombinant Macrophage Colony-Stimulating Factor

NCI Thesaurus Code: C1290 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0079784  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Macrophage Colony Stimulating Factor
Recombinant Colony Stimulating Factor 1
Recombinant Macrophage Colony-Stimulating Factor
rM-CSF

External Source Codes: 
CAS Registry Number 81627-83-0 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 40240
PDQ Open Trial Search ID 40240 (check for NCI PDQ open clinical trial info)
UMLS CUI C0079784

Other Properties:
     Name Value (qualifiers indented underneath)
code C1290
Legacy_Concept_Name Recombinant_Macrophage_Colony-Stimulating_Factor
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1290

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