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Version: 16.11d (Release date: 2016-11-28)
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Carboplatin (Code C1282)

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Terms & Properties

Preferred Name: Carboplatin

Definition: A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. (NCI04)

NCI-GLOSS Definition: A drug that is used to treat advanced ovarian cancer that has never been treated or symptoms of ovarian cancer that has come back after treatment with other anticancer drugs. It is also used with other drugs to treat advanced, metastatic, or recurrent non-small cell lung cancer and is being studied in the treatment of other types of cancer. Paraplatin is a form of the anticancer drug cisplatin and causes fewer side effects in patients. It attaches to DNA in cells and may kill cancer cells. It is a type of platinum compound.

Display Name: Carboplatin

Label: Carboplatin

NCI Thesaurus Code: C1282 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0079083  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum
1,1-cyclobutanedicarboxylic acid platinum complex
Blastocarb
Carboplat
Carboplatin
CARBOPLATIN
carboplatin
Carboplatino
Carboplatin Hexal
Carbosin
Carbosol
Carbotec
CBDCA
cis-diammine(1,1-cyclobutanedicarboxylato) platinum(II)
Cis-Diammine(cyclobutane-1,1-dicarboxylato)platinum
cis-diammine(cyclobutanedicarboxylato)platinum II
Displata
Ercar
JM-8
Nealorin
Novoplatinum
Paraplat
Paraplatin
Paraplatine
Paraplatin AQ
platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2)
Platinwas
Ribocarbo

External Source Codes: 
CAS Registry Number 41575-94-4 (see NLM ChemIDplus info)
FDA UNII Code BG3F62OND5
ChEBI ID CHEBI:31355 (see ChEBI info)
NSC Code 201345 (see NCI DTP info)
NSC Code 241240 (see NCI DTP info)
PDQ Closed Trial Search ID 39176
PDQ Open Trial Search ID 39176 (check for NCI PDQ open clinical trial info)
UMLS CUI C0079083

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Osteogenic sarcoma; CNS and germ cell tumors; ovarian; lung; head and neck; endometrial; esophageal; bladder; breast; cervical cancer.
Chemical_Formula C6H6O4.Pt.2H3N
code C1282
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Carboplatin
Semantic_Type Inorganic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1282

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