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Version: 17.10e (Release date: 2017-10-30)
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Venlafaxine (Code C1278)

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Terms & Properties

Preferred Name: Venlafaxine

Definition: A synthetic phenethylamine bicyclic derivative with antidepressant activity. Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak dopamine reuptake inhibitors. This agent may reduce hormone-related vasomotor symptoms. (NCI04)

NCI-GLOSS Definition: An antidepressant drug that is being evaluated for the treatment of hot flashes in women who have breast cancer.

Display Name: Venlafaxine

Label: Venlafaxine

NCI Thesaurus Code: C1278 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0078569  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 93413-69-5 (see NLM ChemIDplus info)
ChEBI ID CHEBI:9943 (see ChEBI info)
PDQ Closed Trial Search ID 43238
PDQ Open Trial Search ID 43238 (check for NCI PDQ open clinical trial info)
UMLS CUI C0078569

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Anxiety; Depression
Chemical_Formula C17H27NO2
code C1278
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Venlafaxine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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