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Version: 16.11d (Release date: 2016-11-28)
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7-Hydroxystaurosporine (Code C1271)

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Terms & Properties

Preferred Name: 7-Hydroxystaurosporine

Definition: A synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called staurosporine analogues.

Display Name: 7-Hydroxystaurosporine

Label: 7-Hydroxystaurosporine

NCI Thesaurus Code: C1271 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0077681  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(+)-UCN-01
2,3,9,10,11,12-Hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)-8,12-epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)triinden-1-one
7-Hydroxy-staurosporine
7-Hydroxystaurosporine
7-HYDROXYSTAUROSPORINE
8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo[a, g]cyclonona[cde] Trinden-1-one, 2,3,9,10,11, 12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)
UCN-01

External Source Codes: 
CAS Registry Number 112953-11-4 (see NLM ChemIDplus info)
FDA UNII Code 7BU5H4V94A
NSC Code 638850 (see NCI DTP info)
PDQ Closed Trial Search ID 42305
PDQ Open Trial Search ID 42305 (check for NCI PDQ open clinical trial info)
UMLS CUI C0077681

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C28H26N4O4
code C1271
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name _7-Hydroxystaurosporine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1271

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