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Version: 17.06d (Release date: 2017-06-26)
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Adozelesin (Code C1270)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Adozelesin

Definition: An alkylating agent that bind to the DNA minor groove in a sequence-specific manner and form covalent adducts with adenines, resulting in the inhibition of DNA replication and induction of apoptosis. (NCI04)

Label: Adozelesin

NCI Thesaurus Code: C1270 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0077640  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(7bR,8aS)-N-(2-((4,5,8,8a-Tetrahydro-7-methyl-4-oxocyclopropa(c)pyrrolo(3,2-e)indol-2(1H)-yl)carbonyl)indol-5-yl)-2-benzofurancarboxamide
Adozelesin
ADOZELESIN
U-73,975
U-73975

External Source Codes: 
CAS Registry Number 110314-48-2 (see NLM ChemIDplus info)
FDA UNII Code 6N3M4XJR2V
NSC Code 615284 (see NCI DTP info)
PDQ Closed Trial Search ID 41915
PDQ Open Trial Search ID 41915 (check for NCI PDQ open clinical trial info)
UMLS CUI C0077640

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C30H22N4O4
code C1270
Contributing_Source FDA
Legacy_Concept_Name Adozelesin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1270

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