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Version: 17.05e (Release date: 2017-05-30)
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ALK/FAK/Pyk2 Inhibitor CT-707 (Code C126648)

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Terms & Properties

Preferred Name: ALK/FAK/Pyk2 Inhibitor CT-707

Definition: An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK), focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2), with potential antineoplastic activity. Upon administration, ALK/FAK/Pyk2 inhibitor CT-707 selectively binds to and inhibits ALK , FAK and Pyk2. The inhibition leads to disruption of ALK- , FAK- and Pyk2-mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK-, FAK- and Pyk2-overexpressing tumor cells. Expression of these tyrosine kinases is dysregulated in various tumor types; they play a key role in tumor cell migration, proliferation, survival, and tumor angiogenesis.

Label: ALK/FAK/Pyk2 Inhibitor CT-707

NCI Thesaurus Code: C126648 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL503764  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ALK/FAK/Pyk2 Inhibitor CT-707
CT 707

External Source Codes: 
PDQ Closed Trial Search ID 779790
PDQ Open Trial Search ID 779790 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C126648
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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