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Version: 17.06d (Release date: 2017-06-26)
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Trimetrexate Glucuronate (Code C1265)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Trimetrexate Glucuronate

Definition: A lipid soluble methotrexate derivative with potential antineoplastic activity. Trimetrexate glucuronate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate glucuronate also exhibits antiviral activity. (NCI04)

NCI-GLOSS Definition: A drug that belongs to the family of drugs called antimetabolites. It is used in the treatment of pneumocystis carinii pneumonia and is being studied in the treatment of cancer.

Label: Trimetrexate Glucuronate

NCI Thesaurus Code: C1265 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0077209  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2,4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline mono-D-glucuronate
Neutrexin
TRIMETREXATE GLUCURONATE
trimetrexate glucuronate
Trimetrexate Glucuronate

External Source Codes: 
CAS Registry Number 82952-64-5 (see NLM ChemIDplus info)
FDA UNII Code L137U4A79K
NSC Code 352122 (see NCI DTP info)
PDQ Closed Trial Search ID 39764
PDQ Open Trial Search ID 39764 (check for NCI PDQ open clinical trial info)
UMLS CUI C0077209

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Head and neck cancer; Metastatic colorectal adenocarcinoma; Non-small cell lung cancer; Osteogenic sarcoma; Pancreatic adenocarcinoma; Pneumocystitis carinii pneumonia
Chemical_Formula C19H23N5O3.C6H10O7
code C1265
Contributing_Source FDA
Legacy_Concept_Name Trimetrexate_Glucuronate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1265

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