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Version: 17.06d (Release date: 2017-06-26)
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Trilostane (Code C1263)

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Terms & Properties

Preferred Name: Trilostane

Definition: A synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex, resulting in the decreased synthesis of mineralocorticoids and glucocorticoids and the decreased conversion of pregnenolone to progesterone. (NCI04)

Label: Trilostane

NCI Thesaurus Code: C1263 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0077144  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(4Alpha,5alpha,17beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile
2Alpha-cyano-4alpha,5alpha-epoxyandrostan-17beta-ol-3-one
4,5-Epoxy-17-hydroxy-3-oxoandrostane-2-carbonitrile
Desopan
Modrastane
Modrenal
Trilostane
TRILOSTANE
WIN 24,540
WIN 24540

External Source Codes: 
CAS Registry Number 13647-35-3 (see NLM ChemIDplus info)
FDA UNII Code L0FPV48Q5R
ChEBI ID CHEBI:32260 (see ChEBI info)
PDQ Closed Trial Search ID 39812
PDQ Open Trial Search ID 39812 (check for NCI PDQ open clinical trial info)
UMLS CUI C0077144

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H27NO3
code C1263
Contributing_Source FDA
DesignNote This drug has been removed from the US market in 1994.
Legacy_Concept_Name Trilostane
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1263

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