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Version: 17.05e (Release date: 2017-05-30)
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Adenosine-A2A Receptor Antagonist CPI-444 (Code C125659)

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Terms & Properties

Preferred Name: Adenosine-A2A Receptor Antagonist CPI-444

Definition: A small molecule immune checkpoint inhibitor of the adenosine A2A receptor (ADORA2A) with potential antineoplastic activity. Upon oral administration, adenosine-A2A receptor antagonist CPI-444 binds to adenosine A2A receptors expressed on the surface of immune cells, including T-lymphocytes, natural killer (NK) cells, macrophages and dendritic cells (DCs). This prevents tumor-released adenosine from interacting with the A2A receptors on these key immune surveillance cells, thereby abrogating adenosine-induced immunosuppression in the tumor microenvironment. This may stimulate anti-tumor immune responses, resulting in tumor regression.

Display Name: Adenosine-A2A Receptor Antagonist CPI-444

Label: Adenosine-A2A Receptor Antagonist CPI-444

NCI Thesaurus Code: C125659 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL504345  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Adenosine-A2A Receptor-Targeting Agent CPI-444
Adenosine-A2A Receptor Antagonist CPI-444

External Source Codes: 
PDQ Closed Trial Search ID 778585
PDQ Open Trial Search ID 778585 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C125659
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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