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Version: 17.06d (Release date: 2017-06-26)
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Toremifene (Code C1256)

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Terms & Properties

Preferred Name: Toremifene

Definition: A nonsteroidal triphenylethylene antiestrogen. Chemically related to tamoxifen, toremifene is a selective estrogen receptor modulator (SERM). This agent binds competitively to estrogen receptors, thereby interfering with estrogen activity. Toremifene also has intrinsic estrogenic properties, which are manifested according to tissue type or species. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called antiestrogens. Toremifene blocks the effect of the hormone estrogen in the body. It may help control some cancers from growing, and it may delay or reduce the risk of cancer recurrence.

Label: Toremifene

NCI Thesaurus Code: C1256 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0076836  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine
(Z)-4-Chloro-1,2-diphenyl-1[4-[2-(N,N-dimethylamino)ethoxy]phenyl]-1-butene
Farestone
TOREMIFENE
Toremifene
toremifene

External Source Codes: 
CAS Registry Number 89778-26-7 (see NLM ChemIDplus info)
FDA UNII Code 7NFE54O27T
ChEBI ID CHEBI:9635 (see ChEBI info)
PDQ Closed Trial Search ID 41103
PDQ Open Trial Search ID 41103 (check for NCI PDQ open clinical trial info)
UMLS CUI C0076836

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Breast cancer; Desmoid tumors
Chemical_Formula C26H28ClNO
code C1256
Contributing_Source FDA
Legacy_Concept_Name Toremifene
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1256

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