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Version: 17.06d (Release date: 2017-06-26)
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Tiazofurin (Code C1254)

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Terms & Properties

Preferred Name: Tiazofurin

Definition: A synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH); IMPDH is the rate-limiting enzyme for de novo purine synthesis. Inhibition of IMPDH results in reduced levels of guanylates, resulting in the inhibition tumor cell growth in vitro and in vivo. (NCI04)

NCI-GLOSS Definition: An anticancer drug being studied to stop cell growth.

Label: Tiazofurin

NCI Thesaurus Code: C1254 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0076656  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-.beta.-D-Ribofuranosyl-4-thiazolecarboxamide
2-.beta.-D-Ribofuranosylthiazole-4-carboxamide
2-Beta-D-ribofuranosyl-4-thiazolecarboxamide
2-Beta-D-ribofuranosylthiazole-4-carboxamide
4-Thiazolecarboxamide, 2-.beta.-D-ribofuranosyl- (9CI)
4-Thiazolecarboxamide, 2-Beta-D-ribofuranosyl- (9CI)
Riboxamide
TCAR
tiazofurin
Tiazofurin
TIAZOFURIN

External Source Codes: 
CAS Registry Number 60084-10-8 (see NLM ChemIDplus info)
FDA UNII Code ULJ82834RE
NSC Code 286193 (see NCI DTP info)
PDQ Closed Trial Search ID 39717
PDQ Open Trial Search ID 39717 (check for NCI PDQ open clinical trial info)
UMLS CUI C0076656

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H12N2O5S
code C1254
Contributing_Source FDA
Legacy_Concept_Name Tiazofurin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1254

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