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Version: 17.06d (Release date: 2017-06-26)
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Temozolomide (Code C1244)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Temozolomide

Definition: A triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short-lived active compound, monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is due primarily to methylation of DNA at the O6 and N7 positions of guanine, resulting in inhibition of DNA replication. Unlike dacarbazine, which is metabolized to MITC only in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide is administered orally and penetrates well into the central nervous system. (NCI04)

NCI-GLOSS Definition: A drug that is used to treat certain types of brain tumors in adults and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents.

Display Name: Temozolomide

Label: Temozolomide

NCI Thesaurus Code: C1244 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0076080  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide
8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one
CCRG-81045
imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-
Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-
Methazolastone
M & B 39831
M and B 39831
RP-46161
SCH 52365
Temcad
Temodal
Temodar
Temomedac
Temozolomide
temozolomide
TEMOZOLOMIDE

External Source Codes: 
CAS Registry Number 85622-93-1 (see NLM ChemIDplus info)
FDA UNII Code YF1K15M17Y
NSC Code 362856 (see NCI DTP info)
PDQ Closed Trial Search ID 41671
PDQ Open Trial Search ID 41671 (check for NCI PDQ open clinical trial info)
UMLS CUI C0076080

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Malignant glioma (Anaplastic astrocytoma; Anaplastic oligodendrogliomas; Anaplastic oligoastrocytomas; Glioblastoma multiforme); Metastatic melanoma
Chemical_Formula C6H6N6O2
code C1244
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Temozolomide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1244

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