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Version: 17.05e (Release date: 2017-05-30)
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Allodepleted T Cell Immunotherapeutic ATIR101 (Code C123911)

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Terms & Properties

Preferred Name: Allodepleted T Cell Immunotherapeutic ATIR101

Definition: A cell-based immunotherapeutic product containing T-lymphocyte-enriched leukocytes that are devoid of alloreactive T-lymphocytes, that can potentially be used to restore lymphocyte levels after stem cell transplantations and are derived from partially matched (haploidentical) family donors for blood cancer patients who do not have a matching stem cell donor available. Host alloreactive T-cells, which can cause graft-versus-host disease (GVHD), are eliminated from the donor lymphocytes ex vivo using photodynamic therapy. After allogeneic hematopoietic stem cell transplantation (HSCT), allodepleted T cell immunotherapeutic ATIR101 is administered. This maintains a T-cell-mediated immune response against tumor cells and the donor T-cells can prevent opportunistic infections. ATIR101 does not cause severe, acute GVHD. In addition, administration of ATIR101 eliminates the need for immunosuppressants.

Display Name: Allodepleted T Cell Immunotherapeutic ATIR101

Label: Allodepleted T Cell Immunotherapeutic ATIR101

NCI Thesaurus Code: C123911 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL498275  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allodepleted T-cell ImmunotheRapeutics
Allodepleted T Cell Immunotherapeutic ATIR101
ATIR101
Theralux-ATIR

External Source Codes: 
PDQ Closed Trial Search ID 775836
PDQ Open Trial Search ID 775836 (check for NCI PDQ open clinical trial info)
NCI META CUI CL498275

Other Properties:
     Name Value (qualifiers indented underneath)
code C123911
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=Thesaurus&code=C123911

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