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Version: 17.10e (Release date: 2017-10-30)
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Exisulind (Code C1239)

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Terms & Properties

Preferred Name: Exisulind

Definition: An inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. After oral administration, sulindac undergoes extensive biotransformation including irreversible oxidation to sulindac sulfone. Approximately, one half of an administered dose of sulindac is eliminated through the urine, mostly as the conjugated sulfone metabolite. (NCI04)

NCI-GLOSS Definition: A drug being studied in the treatment and prevention of cancer. It has been shown to cause apoptosis (cell death) in cells that are malignant (cancer) and in cells that may become cancer. It acts through a group of cellular enzymes called cGMP phosphodiesterases.

Display Name: Exisulind

Label: Exisulind

NCI Thesaurus Code: C1239 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0075616  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic Acid
1H-Indene-3-acetic Acid, 5-Fluoro-2-methyl-1-((4-(methylsulfonyl)phenyl)methylene), (Z)
Sulindac sulfone
Sulindac Sulfone

External Source Codes: 
CAS Registry Number 59973-80-7 (see NLM ChemIDplus info)
ChEBI ID CHEBI:64212 (see ChEBI info)
NSC Code 719619 (see NCI DTP info)
PDQ Closed Trial Search ID 43057
PDQ Open Trial Search ID 43057 (check for NCI PDQ open clinical trial info)
UMLS CUI C0075616

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Colonic adenomatous polyps in the inherited disease adenomatous polyposis coli, control and suppression
Chemical_Formula C20H17FO4S
code C1239
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Sulindac_Sulfone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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