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Version: 17.05e (Release date: 2017-05-30)
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Akt-1/2 Inhibitor-treated Tumor Infiltrating Lymphocytes (Code C123720)

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Terms & Properties

Preferred Name: Akt-1/2 Inhibitor-treated Tumor Infiltrating Lymphocytes

Definition: Autologous tumor infiltrating lymphocytes (TILs) harvested directly from the infiltrate of a patient's tumor and treated with an inhibitor of the serine/threonine kinases Akt-1 and -2 (Akti-1/2) during ex vivo expansion, with potential antineoplastic activity. Upon reintroduction into the patient, the Akti-1/2-treated TILs recognize and kill cancer cells. Akt inhibition promotes the immunologic memory of the TILs and enhances their expansion, in vivo long-term persistence and antitumor activity.

Display Name: Akt-1/2 Inhibitor-treated Tumor Infiltrating Lymphocytes

Label: Akt-1/2 Inhibitor-treated Tumor Infiltrating Lymphocytes

NCI Thesaurus Code: C123720 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C4055481  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Akt-1/2 Inhibitor-treated Tumor Infiltrating Lymphocytes
Akti-1/2-treated Tumor Infiltrating Lymphocytes
AKTi-treated TIL
AKTi-treated TILs

External Source Codes: 
PDQ Closed Trial Search ID 775186
PDQ Open Trial Search ID 775186 (check for NCI PDQ open clinical trial info)
UMLS CUI C4055481

Other Properties:
     Name Value (qualifiers indented underneath)
code C123720
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=Thesaurus&code=C123720

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