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Version: 17.06d (Release date: 2017-06-26)
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Spiroplatin (Code C1234)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Spiroplatin

Definition: A synthetic derivative of cyclohexane sulfatoplatinum with antineoplastic properties. Spiroplatin induces DNA cross-links, thereby inhibiting DNA replication and RNA and protein synthesis. Similar to other platinum compounds, this agent has been shown to be mutagenic and carcinogenic. (NCI04)

Label: Spiroplatin

NCI Thesaurus Code: C1234 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0075022  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cis-1,1-diamino-methylcyclohexane sulfato-platinum
Platinum, (1,1-cyclohexanedimethanamine-n,n')(sulfato(2-)-O,O')-, (sp-4-2)-
Spiroplatin
SPIROPLATIN
TNO-6

External Source Codes: 
CAS Registry Number 74790-08-2 (see NLM ChemIDplus info)
FDA UNII Code H2V318W7LE
NSC Code 311056 (see NCI DTP info)
PDQ Closed Trial Search ID 39763
PDQ Open Trial Search ID 39763 (check for NCI PDQ open clinical trial info)
UMLS CUI C0075022

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C8H18N2.O4S.Pt
code C1234
Contributing_Source FDA
Legacy_Concept_Name Spiroplatin
Semantic_Type Inorganic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1234

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