Terms & Properties

Preferred Name:  Eluvixtamab

Definition:  A proprietary recombinant bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) CD33 fused to one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of eluvixtamab, this bispecific antibody binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the CD33 antigen found on CD33-expressing tumor cells. This activates and redirects CTLs to CD33-expressing tumor cells, which results in the CTL-mediated cell death of CD33-expressing tumor cells. CD33, a myeloid differentiation antigen, is expressed on normal non-pluripotent hematopoietic stem cells and overexpressed on neoplastic cells in patients with acute myeloid leukemia.

Display Name:  Eluvixtamab

Label:  Eluvixtamab

NCI Thesaurus Code:  C123332 (Search for linked caDSR metadata)   (search value sets)

NCI Metathesaurus Link:  C3851031  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

AMG 330

AMG-330

AMG330

Anti-CD33/CD3 BiTE Antibody AMG 330

Bispecific T-cell Engager Antibody AMG 330

BiTE Antibody AMG 330

CD33/CD3-directed Bispecific T-cell Engager Antibody AMG 330

Eluvixtamab

ELUVIXTAMAB

External Source Codes: 

CAS Registry Number	1679391-73-1 (see NLM ChemIDplus info)
NCI Drug Dictionary ID	775135 (see NCI Drug Dictionary info)
FDA UNII Code	6Z4B5PJ4OP
PDQ Closed Trial Search ID	775135
PDQ Open Trial Search ID	775135
UMLS CUI	C3851031

Other Properties:

Name	Value (qualifiers indented underneath)
code	C123332
Contributing_Source	CTRP
Contributing_Source	FDA
Contributing_Source	GDC
Contributing_Source	HemOnc
Maps_To	Anti-CD33/CD3 BiTE Antibody AMG 330
	Target_Terminology: GDC       Relationship_to_Target: Has Synonym       Target_Term_Type: PT       Target_Code: therapeutic_agents
Semantic_Type	Amino Acid, Peptide, or Protein
Semantic_Type	Immunologic Factor
Semantic_Type	Pharmacologic Substance

Additional Concept Data: 

Defined Fully by Roles: No

URL:https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C123332