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Version: 17.06d (Release date: 2017-06-26)
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Spiromustine (Code C1233)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Spiromustine

Definition: A bifunctional nitrogen alkylating agent with antineoplastic activity and lipophilic properties. Containing a lipophilic hydantoin group that serves as a carrier to cross the blood brain barrier, spiromustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)

Label: Spiromustine

NCI Thesaurus Code: C1233 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0075019  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,3-diazaspiro(4,5)decane-2,4-dione,3-(2-(bis-chloroethyl)amino)ethyl
SHM
Spirohydantoin mustard
Spirohydantoin Mustard
Spiromustine

External Source Codes: 
CAS Registry Number 56605-16-4 (see NLM ChemIDplus info)
NSC Code 172112 (see NCI DTP info)
PDQ Closed Trial Search ID 39441
PDQ Open Trial Search ID 39441 (check for NCI PDQ open clinical trial info)
UMLS CUI C0075019

Other Properties:
     Name Value (qualifiers indented underneath)
code C1233
Legacy_Concept_Name Spiromustine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1233

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