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Version: 16.11d (Release date: 2016-11-28)
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Sodium Thiosulfate (Code C1230)

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Terms & Properties

Preferred Name: Sodium Thiosulfate

Definition: A water soluble salt and reducing agent that reacts with oxidizing agents. Although its exact mechanism of action is unknown, thiosulfate likely provides an exogenous source of sulfur, thereby hastening the detoxification of cyanide through the enzyme rhodanese (thiosulfate cyanide sulfurtransferase) which converts cyanide to the relatively nontoxic, excretable thiocyanate ion. In addition, this agent neutralizes the reactive alkylating species of nitrogen mustard, thereby decreasing skin toxicity related to nitrogen mustard extravasation. (NCI04)

NCI-GLOSS Definition: A substance that is used in medicine as an antidote to cyanide poisoning and to decrease side effects of the anticancer drug cisplatin.

Display Name: Sodium Thiosulfate

Label: Sodium Thiosulfate

NCI Thesaurus Code: C1230 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0074774  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cyanide Antidote Package
Disodium Thiosulfate
Disodium thiosulfate
S-Hydril
Sodium Hyposulfate
Sodium Thiosulfate
SODIUM THIOSULFATE
Sodium thiosulfate
sodium thiosulfate
Sodium Thiosulfate Pentahydrate
Sodium Thiosulphate
Sodothiol
Thiosulfate, Sodium, Pentahydrate
Thiosulfuric Acid Disodium Salt
Thiosulfuric acid disodium salt

External Source Codes: 
CAS Registry Number 10102-17-7 (see NLM ChemIDplus info)
FDA UNII Code HX1032V43M
ChEBI ID CHEBI:32150 (see ChEBI info)
NSC Code 45624 (see NCI DTP info)
PDQ Closed Trial Search ID 39602
PDQ Open Trial Search ID 39602 (check for NCI PDQ open clinical trial info)
UMLS CUI C0074774

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Cisplatin-induced nephrotoxicity; Nitrogen mustard-induced skin toxicity, neutralizer; Poisoning, arsenic and cyanide
Chemical_Formula 2Na.O3S2.5H2O
code C1230
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Sodium_Thiosulfate
Semantic_Type Inorganic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1230

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