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Version: 16.10e (Release date: 2016-10-31)
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Samarium Sm-153 Lexidronam Pentasodium (Code C1220)

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Terms & Properties

Preferred Name: Samarium Sm-153 Lexidronam Pentasodium

Definition: The pentasodium salt of samarium Sm 153 lexidronam, a therapeutic agent consisting of a medium energy beta- and gamma-emitting radioisotope, samarium Sm 153, and a teraphosphonate chelator, ethylenediaminetetramethylene phosphonic acid (EDTMP). The chelator moiety of samarium Sm 153 lexidronam associates with hydroxyapatite crystals concentrated in areas of bone turnover, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to osteoblastic bone metastases.

NCI-GLOSS Definition: A drug used to treat pain caused by bone cancer and other cancers that have spread to the bones. Samarium Sm 153 lexidronam pentasodium is a type of radiopharmaceutical.

Display Name: Samarium Sm-153 Lexidronam Pentasodium

Label: Samarium Sm-153 Lexidronam Pentasodium

NCI Thesaurus Code: C1220 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0772051  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
153Sm-EDTMP
Quadramet
Samarium-153 EDTMP
Samarium-153 Ethylenediaminetetramethylenephosphonate
Samarium-153 Ethylenediaminetetramethylenephosphonic Acid
Samarium Sm-153 EDTMP
Samarium Sm-153 Lexidronam Pentasodium
SAMARIUM SM-153 LEXIDRONAM PENTASODIUM
Samarium Sm 153 Lexidronam
samarium Sm 153 lexidronam pentasodium
Sm-153 EDTMP
Sm 153 Lexidronam Pentasodium

External Source Codes: 
CAS Registry Number 160369-78-8 (see NLM ChemIDplus info)
FDA UNII Code 7389YR3OOV
NSC Code 741196 (see NCI DTP info)
PDQ Closed Trial Search ID 42245
PDQ Open Trial Search ID 42245 (check for NCI PDQ open clinical trial info)
UMLS CUI C0772051

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C6H12N2O12P4.5Na.Sm
code C1220
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Sm_153_Lexidronam_Pentasodium
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1220

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