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Version: 17.06d (Release date: 2017-06-26)
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Ketorolac (Code C1219)

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Terms & Properties

Preferred Name: Ketorolac

Definition: A synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic, and antipyretic activities. Ketorolac non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2. The inhibition of COX-2, up-regulated at sites of inflammation, prevents conversion of arachidonic acid to pro-inflammatory prostaglandins. The inhibition of COX-1 by this agent prevents the normal steady-state production of prostaglandins that play housekeeping roles in the protection of the gastrointestinal tract, the regulation of renal blood flow, and platelet aggregation. As a result, the inhibition of COX-1 may be associated with gastrointestinal toxicity, nephrotoxicity, and the inhibition of platelet aggregation.

Display Name: Ketorolac

Label: Ketorolac

NCI Thesaurus Code: C1219 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0073631  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ketorolac
ketorolac
KETOROLAC

External Source Codes: 
CAS Registry Number 74103-06-3 (see NLM ChemIDplus info)
FDA UNII Code YZI5105V0L
PDQ Closed Trial Search ID 40569
PDQ Open Trial Search ID 40569 (check for NCI PDQ open clinical trial info)
UMLS CUI C0073631

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H13NO3
code C1219
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ketorolac
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1219

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